News of the WeekGenomics

Mouse Sequencers Take Up the Shotgun

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Science  18 Feb 2000:
Vol. 287, Issue 5456, pp. 1179-1181
DOI: 10.1126/science.287.5456.1179

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MARCO ISLAND, FLORIDA-- In a dramatic departure, the genome community will be using a controversial sequencing strategy--one that many scientists have publicly trounced--to tackle its next big target: the mouse. Discussions at a meeting held here last week made clear that a good part of the mouse will be sequenced using the whole-genome shotgun method pioneered by J. Craig Venter of Celera Genomics in Rockville, Maryland. But it will be used in combination with the more incremental strategy used by the Human Genome Project, the publicly funded consortium sequencing the human genome and the genomes of other organisms.