PerspectiveStructural Biology

SRP--Where the RNA and Membrane Worlds Meet

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Science  18 Feb 2000:
Vol. 287, Issue 5456, pp. 1212-1213
DOI: 10.1126/science.287.5456.1212

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Working out how the signal recognition particle (SRP) of cells directs newly synthesized proteins destined for secretion to the endoplasmic reticulum (ER) has proved a gargantuan task. That task has just been made easier, as explained in a Perspective by Peter Walter and colleagues, by the solving of the crystal structure of the RNA-protein core of the SRP ( Batey et al.)