Special Reviews

Out of Eden: Stem Cells and Their Niches

Science  25 Feb 2000:
Vol. 287, Issue 5457, pp. 1427-1430
DOI: 10.1126/science.287.5457.1427

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

Stem cells are currently in the news for two reasons: the successful cultivation of human embryonic stem cell lines and reports that adult stem cells can differentiate into developmentally unrelated cell types, such as nerve cells into blood cells. Both intrinsic and extrinsic signals regulate stem cell fate and some of these signals have now been identified. Certain aspects of the stem cell microenvironment, or niche, are conserved between tissues, and this can be exploited in the application of stem cells to tissue replacement therapy.

View Full Text

Cited By...