Porphyrin and Phthalocyanine Antiscrapie Compounds

+ See all authors and affiliations

Science  25 Feb 2000:
Vol. 287, Issue 5457, pp. 1503-1506
DOI: 10.1126/science.287.5457.1503

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


The transmissible spongiform encephalopathies (TSEs) are fatal, neurodegenerative diseases for which no effective treatments are available. The likelihood that a bovine form of TSE has crossed species barriers and infected humans underscores the urgent need to identify anti-TSE drugs. Certain cyclic tetrapyrroles (porphyrins and phthalocyanines) have recently been shown to inhibit the in vitro formation of PrP-res, a protease-resistant protein critical for TSE pathogenesis. We now report that treatment of TSE-infected animals with three such compounds increased survival time from 50 to 300%. The significant inhibition of TSE disease by structurally dissimilar tetrapyrroles identifies these compounds as anti-TSE drugs.

  • * To whom correspondence should be addressed. E-mail: spriola{at}

View Full Text

Related Content