Review

Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

See allHide authors and affiliations

Science  03 Mar 2000:
Vol. 287, Issue 5458, pp. 1606-1609
DOI: 10.1126/science.287.5458.1606

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

The Wnt cell-cell signaling pathway plays a critical and evolutionarily conserved role in directing cell fates during embryogenesis. In addition, inappropriate activation of the Wnt signal transduction pathway plays a role in a variety of human cancers. Many recent studies of Wnt signaling have provided mechanistic insight into these dual roles. Here we focus on two areas of rapid advance: (i) the machinery that regulates the stability of the key signal transducer, β-catenin, and (ii) the effect of Wnt signaling on cellular targets outside the nucleus, the actin and microtubule cytoskeletons.

  • * To whom correspondence should be addressed. E-mail: peifer{at}unc.edu

View Full Text