Review

Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

Science  03 Mar 2000:
Vol. 287, Issue 5458, pp. 1606-1609
DOI: 10.1126/science.287.5458.1606

You are currently viewing the abstract.

View Full Text

Abstract

The Wnt cell-cell signaling pathway plays a critical and evolutionarily conserved role in directing cell fates during embryogenesis. In addition, inappropriate activation of the Wnt signal transduction pathway plays a role in a variety of human cancers. Many recent studies of Wnt signaling have provided mechanistic insight into these dual roles. Here we focus on two areas of rapid advance: (i) the machinery that regulates the stability of the key signal transducer, β-catenin, and (ii) the effect of Wnt signaling on cellular targets outside the nucleus, the actin and microtubule cytoskeletons.

  • * To whom correspondence should be addressed. E-mail: peifer{at}unc.edu

View Full Text

Cited By...