Tracing Leptin's Partners in Regulating Body Weight

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Science  10 Mar 2000:
Vol. 287, Issue 5459, pp. 1738-1741
DOI: 10.1126/science.287.5459.1738

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Although the hormone leptin hasn't turned out to be a "magic bullet" for obesity, its discovery has stimulated basic lab research which has been sketching out a much clearer picture of just how the body controls its weight. Researchers have identified a wealth of molecules involved in weight regulation, some of which cooperate with leptin to suppress appetite, while others blunt the hormone's fat-busting effects. Combining all these new molecular actors together in one leptin-conducted performance will be a daunting task, but they are already providing new targets for antiobesity drugs.