PerspectiveCELL CYCLE

Piecing Together the p53 Puzzle

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Science  10 Mar 2000:
Vol. 287, Issue 5459, pp. 1765-1766
DOI: 10.1126/science.287.5459.1765

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When the DNA of a cell is damaged, a network of proteins tell the cell to stop at the nearest cell cycle checkpoint so that the DNA repair machinery can set about shoring up the damage and the cell can decide whether to continue proliferating. In a Perspective, Carr discusses new findings ( Hirao et al.) showing that the checkpoint kinase CHK2 regulates a crucial central player in checkpoint pathways-the tumor suppressor protein p53.