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Writing Scrapie's Coda, Codon by Codon?

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Science  17 Mar 2000:
Vol. 287, Issue 5460, pp. 1907
DOI: 10.1126/science.287.5460.1907

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Over the past decade, geneticists have found that different variations, or polymorphisms, in the gene coding for PrP--a cellular protein that many scientists believe becomes infectious when it converts to an abnormal form called a prion--seem to confer varying degrees of susceptibility to scrapie. This correlation raises the possibility that genetically susceptible sheep could be bred out of the population, leaving only scrapie-resistant animals (see main text).