PerspectiveSignal Transduction

Inositol Phosphates in the Nucleus

See allHide authors and affiliations

Science  17 Mar 2000:
Vol. 287, Issue 5460, pp. 1937-1939
DOI: 10.1126/science.287.5460.1937

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


The inositol signaling pathways in the cytoplasm are well characterized. In a Perspective, Chi and Crabtree now explain how similar inositol pathways operate in the nucleus to switch gene expression on and off. One of the key players is the kinase Ipk2p, which might stabilize components of a transcription complex ( Odom et al.).