PerspectiveSignal Transduction

Inositol Phosphates in the Nucleus

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Science  17 Mar 2000:
Vol. 287, Issue 5460, pp. 1937-1939
DOI: 10.1126/science.287.5460.1937

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The inositol signaling pathways in the cytoplasm are well characterized. In a Perspective, Chi and Crabtree now explain how similar inositol pathways operate in the nucleus to switch gene expression on and off. One of the key players is the kinase Ipk2p, which might stabilize components of a transcription complex ( Odom et al.).