Integrating Combinatorial Synthesis and Bioassays

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Science  17 Mar 2000:
Vol. 287, Issue 5460, pp. 1947-1948
DOI: 10.1126/science.287.5460.1947

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The increasing demand for large chemical libraries of potential drug candidates is accompanied by the need for efficient methods for identifying biologically active compounds in these libraries. In this TechView, Rademann and Jung (p. 1947) discuss strategies for creating efficient interfaces between combinatorial synthesis and screening and hereby extracting biologically relevant information from libraries of chemical compounds.