Special Reviews

Harnessing the Power of the Genome in the Search for New Antibiotics

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Science  17 Mar 2000:
Vol. 287, Issue 5460, pp. 1973-1976
DOI: 10.1126/science.287.5460.1973

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Abstract

Over the past 40 years, the search for new antibiotics has been largely restricted to well-known compound classes active against a standard set of drug targets. Although many effective compounds have been discovered, insufficient chemical variability has been generated to prevent a serious escalation in clinical resistance. Recent advances in genomics have provided an opportunity to expand the range of potential drug targets and have facilitated a fundamental shift from direct antimicrobial screening programs toward rational target-based strategies. The application of genome-based technologies such as expression profiling and proteomics will lead to further changes in the drug discovery paradigm by combining the strengths and advantages of both screening strategies in a single program.

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