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A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control

Science  17 Mar 2000:
Vol. 287, Issue 5460, pp. 2026-2029
DOI: 10.1126/science.287.5460.2026

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Abstract

Phospholipase C and two inositol polyphosphate (IP) kinases constitute a signaling pathway that regulates nuclear messenger RNA export through production of inositol hexakisphosphate (IP6). The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae, designated Ipk2, was found to be identical to Arg82, a regulator of the transcriptional complex ArgR-Mcm1. Synthesis of inositol 1,4,5,6-tetrakisphosphate, but not IP6, was required for gene regulation through ArgR-Mcm1. Thus, the phospholipase C pathway produces multiple IP messengers that modulate distinct nuclear processes. The results reveal a direct mechanism by which activation of IP signaling may control gene expression.

  • * To whom correspondence should be addressed. E-mail: yorkj{at}acpub.duke.edu

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