Are Sequencers Ready to 'Annotate' the Human Genome?

Science  24 Mar 2000:
Vol. 287, Issue 5461, pp. 2183
DOI: 10.1126/science.287.5461.2183

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To be useful, a genome must be annotated--that is, documented to provide at a minimum the putative start, stop, and structure of each gene. The genomics community is now scrambling to figure out the best way to annotate the human genome, the rough draft of which is due out this spring. The challenge will be even more daunting than the one faced by fruit fly biologists in analyzing the Drosophila genome (see main text).