From Sequence to Chromosome: The Tip of the X Chromosome of D. melanogaster

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Science  24 Mar 2000:
Vol. 287, Issue 5461, pp. 2220-2222
DOI: 10.1126/science.287.5461.2220

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One of the rewards of having a Drosophila melanogaster whole-genome sequence will be the potential to understand the molecular bases for structural features of chromosomes that have been a long-standing puzzle. Analysis of 2.6 megabases of sequence from the tip of the X chromosome ofDrosophila identifies 273 genes. Cloned DNAs from the characteristic bulbous structure at the tip of the Xchromosome in the region of the broad complex display an unusual pattern of in situ hybridization. Sequence analysis revealed that this region comprises 154 kilobases of DNA flanked by 1.2-kilobases of inverted repeats, each composed of a 350–base pair satellite related element. Thus, some aspects of chromosome structure appear to be revealed directly within the DNA sequence itself.

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