PerspectiveMolecular Biology

RNA Interference

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Science  31 Mar 2000:
Vol. 287, Issue 5462, pp. 2431-2433
DOI: 10.1126/science.287.5462.2431

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Double-stranded RNA can silence the expression of a gene with a corresponding sequence, a process called RNA interference (RNAi). RNAi can be transferred from parent to offspring in the worm. In a Perspective, Sharp and Zamore discuss a new study ( Grishok et al.) that identifies the genes involved in the inheritance of RNAi in C. elegans.