Report

Insect Population Control Using a Dominant, Repressible, Lethal Genetic System

Science  31 Mar 2000:
Vol. 287, Issue 5462, pp. 2474-2476
DOI: 10.1126/science.287.5462.2474

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

A major modification to the sterile insect technique is described, in which transgenic insects homozygous for a dominant, repressible, female-specific lethal gene system are used. We demonstrate two methods that give the required genetic characteristics in an otherwise wild-type genetic background. The first system uses a sex-specific promoter or enhancer to drive the expression of a repressible transcription factor, which in turn controls the expression of a toxic gene product. The second system uses non–sex-specific expression of the repressible transcription factor to regulate a selectively lethal gene product. Both methods work efficiently inDrosophila melanogaster, and we expect these principles to be widely applicable to more economically important organisms.

  • * To whom correspondence should be addressed. E-mail: Luke.Alphey{at}zoo.ox.ac.uk

View Full Text

Cited By...