Receptors as Kissing Cousins

Science  07 Apr 2000:
Vol. 288, Issue 5463, pp. 65-67
DOI: 10.1126/science.288.5463.65

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It has always been assumed that the numerous members of the huge GPCR family of receptors function in isolation. However, as Graeme Milligan discusses in a Perspective, a host of new findings ( Rocheville et al.) now suggest that related but different GPCRs can bind to each other, and when they do their properties are altered.