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A Perpetrator of p53-dependent Apoptosis

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Science  14 Apr 2000:
Vol. 288, Issue 5464, pp. 229
DOI: 10.1126/science.288.5464.229h

The activation of the tumor suppressor protein p53 can lead to cell cycle arrest or to apoptosis. Attardi et al. used subtractive hybridization to identify a gene involved specifically in the p53-dependent apoptosis pathway; PERP (p53 apoptosis effector related to PMP-22) was induced in p53-mediated apoptosis of mouse embryonic fibroblasts, but not in p53-deficient fibroblasts and not in UV-triggered apoptosis. The PERP promoter contained two putative p53 binding sites, and expression of PERP in p53-null cells resulted in cell death, suggesting that this newly identified protein may lie downstream of p53. PERP shares sequence similarity to PMP-22/gas3, a group of plasma membrane proteins connected to human demyelinating peripheral neuropathies such as Charcot-Marie-Tooth.—JN

Genes Dev.14, 704 (2000).

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