IMAGES: Hallmarks of Disease

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Science  21 Apr 2000:
Vol. 288, Issue 5465, pp. 395
DOI: 10.1126/science.288.5465.395a

Many pathologists would recognize the gnarled orange and blue-green plaques above: They are the signature of Alzheimer's disease. The plaques, made of amyloid protein, and neurofibrillary tangles build up in the cerebral cortex of victims, possibly killing neurons. This slide comes from a series of weekly case studies at WebPath, a University of Utah pathology teaching site. Pathology images have become a cottage industry on the Web, with many departments posting their best pictures for medical students and researchers. Visitors can see organs ravaged by cancer, the spongy brain tissue created by Creutzfeldt-Jakob disease, cells invaded by malaria parasites, and more. Another useful site is PathWeb, which includes a search tool that combs pathology image archives across the entire Web.

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