Physiology

Central and Peripheral Views of Leptin

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Science  28 Apr 2000:
Vol. 288, Issue 5466, pp. 577
DOI: 10.1126/science.288.5466.577g

Leptin regulates body weight by reducing food intake and by altering metabolism in peripheral tissues. To investigate leptin's effects, gene profiling was used to catalogue genes whose expression was altered in leptin-deficient obese mice. In a study of pituitary tissue, Renzi et al. found that over 100 genes showed altered expression in leptin-deficient mice, but only five, including the proopiomelanocortin (POMC) and prolactin genes, were normalized by short-term leptin replacement. Working with white adipose tissue, Soukas et al. found dramatic alterations in the expression of hundreds of genes in leptin-deficient mice, including genes regulated by sterol regulatory element-binding protein-1, adipocyte differentiation genes, and many others. In this case, normal expression of a significant fraction of these genes was restored by long-term treatment with leptin.—PAK

J. Biol. Chem.275, 10429 (2000); Genes Dev.14, 963 (2000).

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