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In Contrast to Dolly, Cloning Resets Telomere Clock in Cattle

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Science  28 Apr 2000:
Vol. 288, Issue 5466, pp. 586-587
DOI: 10.1126/science.288.5466.586

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When researchers took a close look at the cells of Dolly, the cloned sheep, they found that her telomeres, the caps on the ends of the chromosomes, were shorter than normal. Because telomere length decreases with age, this was an indication that Dolly might age unusually quickly. But on page 665, a physician and his colleagues report that cells from calves that they cloned have telomeres that are longer than normal. According to the researchers, the findings suggest that tissues produced by cloning might last at least as long as the original cells--and perhaps longer.