PerspectiveGene Therapy

The Best of Times, the Worst of Times

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Science  28 Apr 2000:
Vol. 288, Issue 5466, pp. 627-629
DOI: 10.1126/science.288.5466.627

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The recent tragic death of a young gene therapy patient has marred the field of gene therapy research. Yet, as Anderson explains in a Perspective, encouraging new results from a study in which a severe immunodeficiency disease is corrected in two infants by delivery of the defective gene ( Cavazzana-Calvo et al.) have brought cautious optimism back to the gene therapy field.