PerspectiveNeurobiology

Of Flies and Mice

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Science  28 Apr 2000:
Vol. 288, Issue 5466, pp. 631-632
DOI: 10.1126/science.288.5466.631

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Summary

Parkinson's disease (PD) is one of the commonest neurodegenerative diseases of old age but its causes remain unclear. It is known that a cardinal feature of the disease is loss of dopamine neurons in the substantia nigra of the brain with concomitant loss of motor control. Several genes that are mutated in the rare inherited form of the disease have been discovered. Now, as Dawson outlines, two recent papers report the first animal models of PD in flies and mice, fueling optimism that there will be rapid further progress in working out the pathogenesis of this disease and in designing more effective treatments.

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