PerspectiveStructural Biology

Light at the End of the Channel

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Science  28 Apr 2000:
Vol. 288, Issue 5466, pp. 632-633
DOI: 10.1126/science.288.5466.632

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For 20 years, Kornberg and his group have doggedly tried to solve the riddle of the structure of Pol II, the eukaryotic multisubunit RNA polymerase that is a colossus among enzymes. As Joan and Ronald Conaway discuss in their Perspective, Kornberg's group have now achieved this goal, revealing to the world the 3.5 Å resolution x-ray crystal structure of yeast Pol II ( Cramer et al.)