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Location of a Major Susceptibility Locus for Familial Schizophrenia on Chromosome 1q21-q22

Science  28 Apr 2000:
Vol. 288, Issue 5466, pp. 678-682
DOI: 10.1126/science.288.5466.678

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Abstract

Schizophrenia is a complex disorder, and there is substantial evidence supporting a genetic etiology. Despite this, prior attempts to localize susceptibility loci have produced predominantly suggestive findings. A genome-wide scan for schizophrenia susceptibility loci in 22 extended families with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity logarithm of the likelihood of linkage (lod) score of 6.50. This linkage result should provide sufficient power to allow the positional cloning of the underlying susceptibility gene.

  • * To whom correspondence should be addressed. E-mail: brzustowicz{at}axon.rutgers.edu

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