Making Sense of Sequence

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Science  05 May 2000:
Vol. 288, Issue 5467, pp. 773
DOI: 10.1126/science.288.5467.773a

A series of articles describe the results of the Drosophila Genome Annotation Assessment Project (, a collaboration of 12 research groups formed to evaluate computational tools currently available for the analysis of genome sequence. All of these groups were examining the same sequence, 2.9 Mb centered on the Adh gene of Drosophila. This region has been studied extensively for 20 years and is known to include genes of varying complexity, including one with 30 exons and some that were located within the introns of other genes. The groups used computer programs to develop predictions based on ab initio gene identification, promoter recognition, EST and cDNA alignment, protein similarity, repetitive sequence identification, and gene function.

Stormo describes the basic principles of genome annotation; Reese et al. present an overview of how the project was designed and how results were evaluated; and Ashburner presents a summary of the findings, from the expected to the surprising.—BJ

Genome Res.10 (2000).

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