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Sog Blocks Gbb, Supersog Blocks Gbb and Dpp

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Science  05 May 2000:
Vol. 288, Issue 5467, pp. 773
DOI: 10.1126/science.288.5467.773h

Two members of the bone morphogenetic protein (BMP) family of growth factors in Drosophila are encoded by the genes decapentaplegic (dpp) and glass-bottom boat (gbb). Yu et al. studied the effects of short gastrulation (sog) on wing development in adult flies and found that Sog abrogates signaling by the Gbb protein and not signaling by Dpp. Truncated forms of Sog, called Supersog, were observed in embryonic and pupal cells but not larval cells, suggesting that Sog is processed in vivo in a developmentally regulated manner. Expression of Supersog led to inhibition of both Dpp signaling and Gbb signaling. Although the metalloproteinase Tolloid (Tld) has been shown to degrade Sog to an inactive form, Yu et al. present evidence that Sog is proteolytically processed into Supersog by a complex of Tld and the Twisted Gastrulation (Tsg) protein. That is, whereas Tld alone degrades Sog, the subsequent expression of Tsg appears to modify Tld proteolytic activity, leading to the formation of Supersog. This may establish the gradient required to regulate Dpp activity and subsequent differentiation of the dorsal region.—JN

Development127, 2143 (2000).

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