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Apoptotic Signals at the Golgi

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Science  19 May 2000:
Vol. 288, Issue 5469, pp. 1139
DOI: 10.1126/science.288.5469.1139d

Caspases are proteases that mediate a sequence of events leading to apoptosis or programmed cell death. Mancini et al. show that caspase-2 localizes primarily to the cytoplasmic face of the Golgi complex (which disintegrates during apoptosis) and cleaves golgin-160, a Golgi membrane protein implicated in maintaining Golgi integrity and membrane trafficking. When a caspase-resistant form of golgin-160 was overexpressed in cultured cells, Golgi disintegration was delayed in response to apoptosis-inducing agents. These data support the notion that specific caspases may localize to distinct intracellular sites in the course of transducing apoptotic signals.—LC

J. Cell Biol.149, 603 (2000).

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