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Zebrafish Earns Its Stripes in Genetic Screens

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Science  19 May 2000:
Vol. 288, Issue 5469, pp. 1160-1161
DOI: 10.1126/science.288.5469.1160

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COLD SPRING HARBOR, NEW YORK-- Because it is a vertebrate, the zebrafish is genetically closer to humans than flies or worms, and its small size, quick generation time, and inexpensive care make it possible to keep thousands of fish in a single lab. Add to that the transparency of its young, and you have what some consider an ideal lab animal. As was demonstrated at a recent meeting here, researchers are using various clever techniques to identify zebrafish mutants with which to probe the genes involved in a wide variety of human maladies, from obesity to bone diseases.