Review

Splitting the Chromosome: Cutting the Ties That Bind Sister Chromatids

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Science  26 May 2000:
Vol. 288, Issue 5470, pp. 1379-1384
DOI: 10.1126/science.288.5470.1379

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Abstract

In eukaryotic cells, sister DNA molecules remain physically connected from their production at S phase until their separation during anaphase. This cohesion is essential for the separation of sister chromatids to opposite poles of the cell at mitosis. It also permits chromosome segregation to take place long after duplication has been completed. Recent work has identified a multisubunit complex called cohesin that is essential for connecting sisters. Proteolytic cleavage of one of cohesin's subunits may trigger sister separation at the onset of anaphase.

  • * To whom correspondence should be addressed. E-mail: nasmyth{at}nt.imp.univie.ac.at

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