Neuronal Plasticity: Increasing the Gain in Pain

See allHide authors and affiliations

Science  09 Jun 2000:
Vol. 288, Issue 5472, pp. 1765-1768
DOI: 10.1126/science.288.5472.1765

You are currently viewing the abstract.

View Full Text


We describe those sensations that are unpleasant, intense, or distressing as painful. Pain is not homogeneous, however, and comprises three categories: physiological, inflammatory, and neuropathic pain. Multiple mechanisms contribute, each of which is subject to or an expression of neural plasticity—the capacity of neurons to change their function, chemical profile, or structure. Here, we develop a conceptual framework for the contribution of plasticity in primary sensory and dorsal horn neurons to the pathogenesis of pain, identifying distinct forms of plasticity, which we term activation, modulation, and modification, that by increasing gain, elicit pain hypersensitivity.

  • * To whom correspondence should be addressed. E-mail: woolf.clifford{at}

View Full Text