PerspectiveMolecular Biology

Telomeres Keep On Rappin'

Science  23 Jun 2000:
Vol. 288, Issue 5474, pp. 2141-2142
DOI: 10.1126/science.288.5474.2141

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Many molecules help maintain the ends of chromosomes, which get chewed off as cells age. Lundblad in her provocative Perspective now tells us about another protein, hRap1, that regulates the length of telomeres in human cells with the help of the TRF proteins. The homology between hRap1 and its counterpart in yeast suggests how the complex molecular machinery needed to maintain chromosome ends may have evolved.