A Degrading Way to Make an Organ

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Science  23 Jun 2000:
Vol. 288, Issue 5474, pp. 2142-2143
DOI: 10.1126/science.288.5474.2142

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Working out how organs form during embryonic development is a fascinating area of research. In a witty Perspective, Jeff Hardin describes new findings ( Nishiwaki et al. ) that reveal the many intricate steps needed for gonads to form in the worm C. elegans. Two key players, GON-1 and MIG-17, are metalloproteases that may help migration of distal tip cells by degrading extracellular matrix components.