Is AIDS in Africa a Distinct Disease?

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Science  23 Jun 2000:
Vol. 288, Issue 5474, pp. 2153-2155
DOI: 10.1126/science.288.5474.2153

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In Africa, opportunistic infections, transmission patterns, and viral subtypes differ from what is seen in the AIDS epidemics of the United States and Europe, yet 2 decades into the epidemic, AIDS researchers have only a shaky handle on the fundamental question: What accounts for these differences? The answers have potentially important implications for both prevention and treatment strategies.