A Metalloprotease Disintegrin That Controls Cell Migration in Caenorhabditis elegans

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Science  23 Jun 2000:
Vol. 288, Issue 5474, pp. 2205-2208
DOI: 10.1126/science.288.5474.2205

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In Caenorhabditis elegans, the gonad acquires two U-shaped arms by the directed migration of its distal tip cells (DTCs) along the body wall basement membranes. Correct migration of DTCs requires the mig-17 gene, which encodes a member of the metalloprotease-disintegrin protein family. The MIG-17 protein is secreted from muscle cells of the body wall and localizes in the basement membranes of gonad. This localization is dependent on the disintegrin-like domain of MIG-17 and its catalytic activity. These results suggest that the MIG-17 metalloprotease directs migration of DTCs by remodeling the basement membrane.

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