Report

Requirement of Mis6 Centromere Connector for Localizing a CENP-A-Like Protein in Fission Yeast

Science  23 Jun 2000:
Vol. 288, Issue 5474, pp. 2215-2219
DOI: 10.1126/science.288.5474.2215

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Abstract

Mammalian kinetochores contain the centromere-specific histone H3 variant CENP-A, whose incorporation into limited chromosomal regions may be important for centromere function and chromosome segregation during mitosis. However, regulation of CENP-A localization and its role have not been clear. Here we report that the fission yeast homolog SpCENP-A is essential for establishing centromere chromatin associated with equal chromosome segregation. SpCENP-A binding to the nonrepetitious inner centromeres depended on Mis6, an essential centromere connector protein acting during G1-S phase of the cell cycle. Mis6 is likely required for recruiting SpCENP-A to form proper connection of sister centromeres.

  • * To whom correspondence should be addressed. E-mail: yanagida{at}kozo.biophys.kyoto-u.ac.jp

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