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Enzyme Blocker Prompts Mice to Shed Weight

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Science  30 Jun 2000:
Vol. 288, Issue 5475, pp. 2299-2300
DOI: 10.1126/science.288.5475.2299a

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Summary

A multidisciplinary team may have discovered an important new weapon in the battle of the bulge. On page 2379 of this issue, the team reports that a molecule that is needed for fat synthesis in the body may play a key role in appetite signaling in the brain. Moreover, the investigators produced a synthetic inhibitor of this molecule that spurred a dramatic drop in appetite and weight in mice.