PerspectiveMicrobiology

Redefining Virology

See allHide authors and affiliations

Science  30 Jun 2000:
Vol. 288, Issue 5475, pp. 2327-2328
DOI: 10.1126/science.288.5475.2327

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Summary

Viruses have always been classified according to whether their genome is composed of DNA or RNA. That may be set to change with the discovery that human cytomegalovirus has both a DNA genome and four mRNA transcripts that are produced before the DNA genome is transcribed after infection of the host cell (Bresnahan and Shenk). As Roizman points out in a lively Perspective, finding out what the proteins encoded by these four mRNAs do, and whether other DNA viruses show this sneaky partnering of DNA and RNA, will keep virologists busy for many years to come.