News of the WeekDNA IMAGING

Getting a Feel for Genetic Variations

See allHide authors and affiliations

Science  07 Jul 2000:
Vol. 289, Issue 5476, pp. 27-28
DOI: 10.1126/science.289.5476.27a

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


A team of researchers has come up with a novel atomic imaging microscope that may dramatically speed the task of linking genetic variants to diseases. The microscope is a modification of the popular atomic force microscope (AFM), which uses an ultrasharp tip to map surfaces of everything from computer chips to DNA at the atomic level. By using this molecule-sized tip, the researchers were able get their AFM to march down a strand of DNA and identify uniquely shaped reporter molecules engineered to tag the genetic variations.