Report

An Inherited Functional Circadian Clock in Zebrafish Embryos

+ See all authors and affiliations

Science  14 Jul 2000:
Vol. 289, Issue 5477, pp. 297-300
DOI: 10.1126/science.289.5477.297

You are currently viewing the abstract.

View Full Text

Abstract

Circadian clocks are time-keeping systems found in most organisms. In zebrafish, expression of the clock genePeriod3 (Per3) oscillates throughout embryogenesis in the central nervous system and the retina.Per3 rhythmic expression was free-running and was reset by light but not by the developmental delays caused by low temperature. The time of fertilization had no effect on Per3 expression.Per3 messenger RNA accumulates rhythmically in oocytes and persists in embryos. Our results establish that the circadian clock functions during early embryogenesis in zebrafish. Inheritance of maternal clock gene products suggests a mechanism of phase inheritance through ovogenesis.

  • * To whom correspondence should be addressed. E-mail: vincent.laudet{at}ens-lyon.fr

View Full Text

Related Content