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Protease Inhibitor Side Effects

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Science  21 Jul 2000:
Vol. 289, Issue 5478, pp. 363
DOI: 10.1126/science.289.5478.363c

Administration of HIV protease inhibitors, while beneficial to AIDS patients, often results in serious side effects; for instance, patients may develop insulin resistance that leads to type 2 diabetes. Murata et al. studied the effects of the HIV protease inhibitors indinavir, ritonavir, and amprenavir on glucose transport and found that glucose uptake in 3T3-L1 cells via the transporter Glut4 was severely reduced. Because this transporter is responsible for the insulin-stimulated glucose uptake into muscle and fat, this result suggests a direct connection between protease inhibitors and the development of insulin resistance, and perhaps other disruptions of lipid metabolism. — JN

J. Biol. Chem.275, 20251 (2000).

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