News of the WeekMolecular Biology

Targeting Intron Insertion Into DNA

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Science  21 Jul 2000:
Vol. 289, Issue 5478, pp. 374
DOI: 10.1126/science.289.5478.374

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In work reported on page 452, researchers have found a way to coax certain introns, bits of genetic debris that litter the DNA and interrupt the coding sequences of many genes, to hop into the exact sequences where the researchers want them. The method could enhance all sorts of genetic manipulations, from studying basic gene function to combating viral infections to delivering genes for gene therapy.