PerspectiveCell Biology

ER-to-Golgi Traffic--This Bud's for You

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Science  21 Jul 2000:
Vol. 289, Issue 5478, pp. 403-404
DOI: 10.1126/science.289.5478.403

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How do protein-transporting vesicles, which bud from the endoplasmic reticulum (ER), specifically dock to, and fuse with, the Golgi apparatus? In their Perspective, Brittle and Waters discuss new work ( Allan et al.) suggesting that some vesicle-associated docking and fusion proteins are "programmed" during vesicle budding from the ER and direct downstream events that occur during fusion of these transport vesicles with the membranes of the Golgi.