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Clocking the Cell Cycle

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Science  28 Jul 2000:
Vol. 289, Issue 5479, pp. 511
DOI: 10.1126/science.289.5479.511a

One of the consequences of genomic sequencing projects and subsequent gene annotations is the development of DNA microarrays, which offer a facile method for rapidly analyzing the temporal patterns of gene expression in whole organisms. Holter et al. have adapted a standard analysis to organize and thus simplify these large data sets, as exemplified by applying this analysis to previously published observations of the yeast cell cycle (cellcycle-http://www.stanford.edu/). They are able to characterize the patterns as consisting largely of two sinusoidal modes, each with a period of 2 hours and about 30 minutes out of phase. Plotting the weights of these two functions for each gene monitored provides a graphical representation of a relatively gradual sequence of which genes turn on and off (starting at about 9 o'clock and moving clockwise) as a yeast cell progresses through the mitotic cell cycle. — GJC

Proc. Natl. Acad. Sci. U.S.A. 97, 8409 (2000).

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