STKE: Escorting RXR Out of the Nucleus

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Science  04 Aug 2000:
Vol. 289, Issue 5480, pp. 699c
DOI: 10.1126/science.289.5480.699c

Staying in the nucleus is certainly important for nuclear receptors like the retinoid-X receptor (RXR) to regulate transcription, and this localization may well depend on which other nuclear receptors RXR partners with. Katagiri et al. report that when RXR heterodimerizes with an orphan nuclear receptor called NGFI-B, RXR is promptly escorted out of the nucleus in response to nerve growth factor (NGF) treatment. When a putative nuclear export signal was mutated in NGFI-B, translocation of both nuclear receptors to the cytoplasm was inhibited, indicating that NGFI-B regulates the subcellular distribution of RXR through heterodimerization. The presence of NGFI-B also interfered with the DNA binding activity of another heterodimer comprised of RXR and the retinoic acid receptor, and treatment of cells with NGF decreased retinoic acid-induced transcription. Thus, RXR-NGFI-B association may be a point of crosstalk between the NGF and retinoic acid signaling pathways. — LDC

Nature Cell Biol. 2, 435 (2000).

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