News of the WeekClinical Research

Flawed Cancer Study Leads to Shake-Up at University of Oklahoma

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Science  04 Aug 2000:
Vol. 289, Issue 5480, pp. 706-707
DOI: 10.1126/science.289.5480.706

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Allegations of lax safety procedures and flawed management in a clinical cancer trial have cost four researchers and administrators their jobs at the University of Oklahoma. They have also led to a temporary shutdown of 75 clinical trials at the university's Health Science Center in Tulsa and a sweeping overhaul of the school's process for approving human experiments. University officials emphasize that none of the roughly 100 patients involved in the 3-year-old study of an experimental cancer vaccine was known to have been harmed, and that most trials will soon be restarted.