News of the WeekMicrobiology

A Weak Link in TB Bacterium Is Found

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Science  18 Aug 2000:
Vol. 289, Issue 5482, pp. 1123-1125
DOI: 10.1126/science.289.5482.1123a

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The secret of the success of Mycobacterium tuberculosis, the pathogen that causes tuberculosis, is that it can linger undetected in the lungs for decades, hiding from the immune system's macrophages that aim to chew it up and spit it out. Now a team of researchers has uncovered a vulnerability in this resilient bug that suggests new ways to starve it out of its bolt-hole.