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Science  18 Aug 2000:
Vol. 289, Issue 5482, pp. 1141
DOI: 10.1126/science.289.5482.1141b

In the course of carrying out experiments that were a direct extension of our recent Science paper “Stable RNA/DNA hybrids in the mammalian genome: inducible intermediates in immunoglobulin class switch recombination” (1), we discovered differences from those in the paper. The first author (R. B. Tracy) has admitted to data alteration such that the primary conclusions of the paper are in question. Because of this, the authors are retracting the entire paper on class switch recombination (1). We are deeply regretful for any scientific misconceptions that have resulted from these studies. [Note that the following related paper is also being retracted for the same reason: R. B. Tracy and M. R. Lieber, “Transcription-dependent R-loop formation at mammalian class switch sequences,” EMBO J. 19, 1055 (2000).]


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